Fig. 1
From: TRIM family contribute to tumorigenesis, cancer development, and drug resistance
Structural classification of TRIM family members. The majority of TRIM proteins contain an N-terminal RING domain, one or two B-box domains (B1, B2) and a coiled-coil domain (CC) and are classified into 11 subfamilies (C-I-C-XI) based on a variable C-terminal domain. There is an additional unclassified group lacking a RING domain. SPRY named from SPla and the RYanodine receptor, PRY-SPRY associated domain, NHL-NCL1, HT2A and LIN41 domain, PHD plant homeodomain, COS cos-box, FN3 fibronectin type III, ARF-ADP ribosylation factor domain, ACID acid-rich region, TM transmembrane region, MATH meprin and TRAF-homology domain, Filamin-filamin-type I G domain, BROMO-bromodomain