Fig. 2From: Unraveling the structures, functions and mechanisms of epithelial membrane protein family in human cancersMissense substitution of PMP22 protein family. A Schematic view of structure of the PMP22 family of proteins. The pink area represents the cytoplasmic domain, the gray represents the transmembrane domain, and the blue represents the extracellular domain. The upper numbers refer to the starting amino acid sites of different domains, and the lower dotted line refers to the mutated amino acid sites. B Missense substitution of PMP22 protein family. The protein structures were modelled by AlphaFold2 [13]. Only the sites with mutation frequency greater than 2 were shown in the dataBack to article page