Fig. 7

CircRIC8B involved in the progression of CLL by sponging miR-199b-5p. MEC-1 and JVM-3 were transfected with si-circRIC8B and/or miR-199b-5p inhibitors. A, B Cell proliferation was determined by CCK-8 assay. Lipid accumulation was determined by C Nile red staining and quantitatively analysed by D MFI. Scale bar, 10 μm. E TG contents. F–H Correlation analysis between circRIC8B, miR-199b-5p, and LPL expression levels in 63 CLL samples determined by qRT-PCR. Data are shown as means ± SD (n = 3, ns, no significant, ^*P < 0.05, ^**P < 0.01, ^***P < 0.001)