From: The genomic analysis brings a new piece to the molecular jigsaw of idiopathic erythrocytosis
SNP | Genotype | Control (503) | Case (80) |
---|---|---|---|
rs3780367 | HWE = 0.6868 | HWE = 0.4974 | HWE = 0.3501 |
T/T | 271 (53.9%) | 27 (33.8%) | |
T/G | 192 (38.2%) | 43 (53.8%) | |
G/G | 40 (8%) | 10 (12.5%) |
Genetic inherytance model | OR (95% CI) | p-value | AIC |
---|---|---|---|
Codominant | 2.23 (1.33, 3.74) | 0.0036866 | 461.1 |
Dominant | 2.29 (1.4, 3.76) | 0.0007576 | 458.9 |
Recessive | 1.65 (0.79, 3.46) | 0.1991234 | 468.6 |
Overdominant | 1.88 (1.17, 3.03) | 0.0089603 | 463.4 |
log-Additive | 1.75 (1.23, 2.47) | 0.0019041 | 460.6 |
Adjustment by single covariates | |||
CALR rs1049481_G (yes/no) | 2.3 (1.4, 3.78) | 0.0007354 | 459.5 |
Gender | 2.62 (1.54, 4.43) | 0.000255 | 362.9 |
Epo level | 2.73 (1.59, 4.68) | 0.000153 | 417.1 |
Adjustment by multiple covariates | |||
Sex-Epo level and CALR rs1049481_G (yes/no) | 3.13 (1.76, 5.5) | 0.000051 | 331.9 |