Table 3 Drugs associated with PD-L1 regulation

Stri-201

STAT3-PD-L1

↓HNSCC[130]

mouse

Nexturastat

Tubastatin A

HDAC6-STAT3-PD-L1

↓melanoma[131]

cell

Silvestrol

EIF4F-STAT1-PD-L1

↑melanoma[132]

mouse

Verteporfin

STAT1-IRF1-TRIM28

↓multiple cancers[133]

cell

Verticillin A

MLL1- H3K4me3

↓PC[134]

cell

Cisplatin

miR-145- c-MYC-PD-L1

↑ovarian carcinoma[135]

cell

PROTACs

PD-L1 ubiquitination and lysosomal degradation

↓multiple cancers[138, 139]

mouse

PD-LYSO

HIP1R-PD-L1

↓multiple cancers[140]

cell

Crcumin

CSN5-PD-L1

↓BC[97]

mouse

Decitabine

DNA hypomethylation

↑CC, leukemia, HNSCC, NSCLC [60, 142,143,144]

mouse

Temozolomide

STAT3-PD-L1

↑glioblastoma multiforme[145]

mouse

Regorafenib

RET-Src-JAK1/2-STAT1;

RET-Src- MAPK signaling

↑melanoma[146]

mouse

Mifepristone

glucocorticoid receptor-PD-L1

↓PC[147]

mouse

Metformin

PD-L1 glycosylation

↓breast tumor, melanoma, and colon cancer[109, 148]

mouse

Capmatinib

MET-PD-L1

↓PC[149]

mouse

Albendazole

PD-L1 ubiquitination

↓melanoma[101]

mouse