Table 1 MicroRNAs were demonstrated to modulate PD- L1 in cancer cells in recent research

miR-138-5p

CC

↓

PD-L1

[161]

miR-148a-3p

↓

PD-L1

[162]

miR-15a

↓

HOXC4

MiR-15a inhibits PD-L1 expression via binding to homeobox C4 (HOXC4).

[163]

miR-20b-21, miR-130b

↑

PTEN

MiR-20b, -21, and − 130b promote PD-L1 expression via restraining PTEN.

[164]

miR-152

GC

↓

PD-L1

[165, 166]

miR-16-5p

↓

PD-L1

[167]

miR-200b

↓

PD-L1

[166]

miR-140

NSCLC

↓

PD-L1

[168]

miR-377-3p

↓

PD-L1

[169]

miR-34

↓

PD-L1

[58]

miR-3127-5p

↑

STAT3

MiR-3127-5p induces upregulation of PD-L1 expression by regulating the expression of p-STAT3.

[170]

miR-197

↓

CKS1B

MiR-197/CKS1B/STAT3 inhibits PD-L1 expression.

[171]

miR-155-5p

LUAD

↓

PD-L1

[172]

miR-320a

MM

↓

PD-L1

[173]

miR-let-7b

LC

↓

PD-L1

[174]

miR-4759

BC

↓

PD-L1

[175]

miR-27a-3p

↑

MAGI2

MiR-27 A-3p upregulates PD-L1 via the membrane-associated guanylate kinase inverted 2 (MAGI2) /PTEN/PI3K axis and together promotes immune escape from BC.

[176]

miR-92

↑

LATS2

MiR-92 binds to large tumor suppressor kinase 2 (LATS2) which is capable to interact with Yes1 associated transcriptional regulator (YAP1) to promote PD-L1 expression.

[177]

miR-424

OC

↓

PD-L1

[178]

miR-142-5p

PC

↓

PD-L1

[179]

miR-129-5P

DLBCL

↓

ARID3A

MiR-129-5p inhibits AT-rich interaction domain 3 A (ARID3A) and thereby downregulates PD-L1 expression.

[180]

miR-329-3p

HCC

↓

KDM1A

MiR-329-3p inhibits PD-L1 expression and enhances response to T cell-induced HCC cytotoxicity by targeting lysine-specific demethylase 1 A (KDM1A).

[181]

miR-155

Multiple cancers

↓

PD-L1

[182]

miR-200

↓

PD-L1

[71]

miR-let-7a/c/e

↓

PD-L1

[183]