Table 2 Reprogrammed signaling pathways associated with metabolism in CLL
From: Targeting metabolic reprogramming in chronic lymphocytic leukemia
Pathways | Mechanism of action |
|---|---|
NF-κB signaling pathway | Constitutively activated and interacts with BCR, Toll-like receptors and CD40 in CLL |
PI3K/AKT/mTOR pathway | Constitutively activated and plays a pivotal role in the aberrant OXHPHOS and glycolysis and involves in CLL cell survival and migration |
Notch-c-Myc signaling pathway | Increases aerobic glycolysis in CLL cells activated by bone marrow stromal cells |
BCR signaling pathways | Engages glucose and glycerol metabolism |