Fig. 6

Anti-tumor immune responses induced by BP210-T315I-RAE-1γ-Dex in the BCR-ABL^T315I-induced CML mouse model. a Peripheral WBC counts were analyzed. b, c The weights of the liver (b) and spleen (c) were recorded. d Wright’s staining showed abnormal leukemic cells (arrows) in bone marrow, spleen and liver tissues. Scale bar, 10 μm. e Histological sections stained with H&E showed the infiltration of leukemic cells (arrows). Scale bar, 10 μm. f The BCR-ABL oncoprotein was identified with a fluorophore-labeled antibody in the liver and spleen and observed under a microscope. Scale bar, 25 μm. g The survival rates of tumor-bearing mice were measured by Kaplan–Meier methods. *p < 0.05, **p < 0.01, ***p < 0.001