Fig. 5

Therapeutic effects of BP210-RAE-1γ-Dex in a murine BP210 tumor model. a The average of the maximum WBC count of every group was calculated. b, c The liver (b) and spleen (c) were harvested and weighed. d Representative images of tissue smears stained with Wright’s staining are shown. The black arrows point to abnormal cells invading tissues. Scale bar, 10 μm. e Hematoxylin and eosin-stained liver and spleen tissues were used to confirm pathological characteristics. The arrows indicate leukemic cells. Scale bar, 10 μm. f Immunofluorescence assays were conducted to determine the level of BCR-ABL expression. Scale bar, 25 μm. g Kaplan–Meier survival analysis was performed to analyze the survival times of treated mice. *p < 0.05, **p < 0.01, ***p < 0.001