Table 1 The clinical characteristics of the 45 patients
Total (N = 45) | TP53 del (N = 14) | TP53 mut (N = 22) | TP53 del & mut (N = 9) | |
|---|---|---|---|---|
Gender | ||||
Male | 25 (55.6%) | 9 (64.3%) | 10 (45.5%) | 6 (66.7%) |
Female | 20 (44.4%) | 5 (35.7%) | 12 (54.5%) | 3 (33.3%) |
Age | 27 (14–67) | 21(14–57) | 32 (14–53) | 26 (14–59) |
Diagnosis | ||||
B-ALL | 35 (77.8%) | 9 (64.3%) | 17 (77.3%) | 9 (100%) |
T-ALL | 10 (22.2%) | 5 (35.7%) | 5 (22.7%) | 0 |
WBC count | 5.35 (0.73–245) | 3.06 (0.73–245) | 8.3 (1.03–100.77) | 4.73 (1.21–47.6) |
Cytogenetic stratificationa | ||||
Standard risk | 35 (77.8%) | 14 (100%) | 16 (72.7%) | 5 (55.6%) |
High risk | 10 (22.2%) | 0 | 6 (27.3%) | 4 (44.4%) |
CRb | 41 (100%) | 12(100%) | 20 (100%) | 9 (100%) |
MRD (3rd month)c | ||||
Negative | 23 (67.6%) | 7 (87.5) | 11 (64.7%) | 5 (55.6%) |
Positive | 11 (32.4%) | 1 (12.5%) | 6 (35.3%) | 4 (44.4%) |
HSCT (41 CR patients) | ||||
Yes | 30 (73.2%) | 9 (75%) | 14 (70%) | 7 (77.8%) |
No | 11 (26.8%) | 3 (25%) | 6 (30%) | 2 (22.2%) |