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Fig. 4 | Experimental Hematology & Oncology

Fig. 4

From: The GPIb-IX complex on platelets: insight into its novel physiological functions affecting immune surveillance, hepatic thrombopoietin generation, platelet clearance and its relevance for cancer development and metastasis

Fig. 4

GPIbα in platelet clearance. Removal of terminal sialic acid from GPIbα O-glycans by neuraminidase leads to an unfolding event of the MSD and additional release of neuraminidases from platelet granules, which desialylate N-glycans on GPIbα. Finally, ADAM17 sheds desialylated GPIbα receptors from the platelet membrane. Platelets with desialylated residues expose galactose and N-acetylgalactosamine that is recognized by the AMR and leads to platelet clearance by hepatocytes and Kupffer cells

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Experimental Hematology & Oncology

ISSN: 2162-3619

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