Fig. 5
Effects of RAM2061 and/or bortezomib treatment in MM mouse xenografts. a Tumor growth curves for MM.1S flank xenografts. (n = 8 mice per group, data are displayed as mean ± SEM, denotes p < 0.01 per mixed-linear mixed model). b Kaplan–Meier curve for MM.1S flank xenografts showing time to sacrifice. Mice were treated twice-weekly with either solvent only control (PBS), RAM2061, Bort, or a combination of RAM2061 and Bort. Mice were euthanized when tumors reached 2000 mm3. * denotes p < 0.05 per long rank test. c Levels of human λ light chain blood samples drawn on day 9 post-initiation of treatment. * denotes p < 0.05, **p < 0.01 and ***p < 0.001 per t-test