A Pig-a conditional knock-out mice model mediated by Vav-iCre: stable GPI-deficient and mild hemolysis

Table 3 Laboratory data of mice

Indicators	Normal C57BL/6N mice	Flox mice	CKO heterozygous mice	CKO homozygous mice	p
WBC (× 10⁹/L)	9.260 ± 2.581	7.827 ± 2.025	3.667 ± 1.347	3.127 ± 1.637	< 0.0001*
RBC (× 10¹²/L)	9.679 ± 0.638	9.309 ± 0.790	7.923 ± 0.902	7.912 ± 0.765	< 0.0001*
Hb (g/L)	152.7 ± 11.07	140.6 ± 10.54	126.1 ± 16.64	120.6 ± 17.22	< 0.0001*
PLT(× 10⁹/L)	1249 ± 130.3	1213 ± 110.2	1106 ± 290.1	987.6 ± 126.9	0.0008*
LDH (U/L)	439.8 ± 45.11	453.1 ± 33.08	586.4 ± 51.83	832.9 ± 208.9	0.0001*
TBIL (μmmol/L)	1.868 ± 0.646	1.834 ± 0.475	3.064 ± 0.480	3.830 ± 0.493	< 0.0001*
IBIL(μmmol/L)	2.006 ± 0.308	1.974 ± 0.385	2.294 ± 0.539	3.318 ± 0.293	0.0032*
FHb (mg/L)	168.1 ± 61.00	179.8 ± 62.15	333.6 ± 137.7	354.1 ± 91.03	0.0052*
C3a (ng/mL)	37.05 ± 5.077	39.56 ± 9.813	46.21 ± 6.659	46.00 ± 7.639	0.1703
C5a (ng/mL)	83.80 ± 13.45	98.82 ± 38.01	124.2 ± 19.53	116.3 ± 28.45	0.1138
C5b-9 (ng/L)	174.3 ± 10.79	193.0 ± 7.10	204.1 ± 6.74	217.2 ± 26.39	0.0027*

ISSN: 2162-3619