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Fig. 5 | Experimental Hematology & Oncology

Fig. 5

From: Exosomes from BM-MSCs promote acute myeloid leukemia cell proliferation, invasion and chemoresistance via upregulation of S100A4

Fig. 5

S100A4 knockdown decreased the proliferation and chemoresistance of leukemia cells after treatment with BM-MSC-exos. a, b S100A4 knockdown decreased the colony formation of KASUMI-1 cells induced by BM-MSC-exos. c, d S100A4 knockdown reduced the colony formation of THP-1 cells induced by BM-MSC-exos. Scale bar for KASUMI-1 and THP-1: 100 μm. e CCK-8 assay was performed to observe the survival of THP-1 cells after Ara-C (32 μM) treatment with NC-siRNA, NC-siRNA + Exos, S100A4-siRNA, and S100A4-siRNA + Exos (*P < 0.05; n.s., not significant)

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Experimental Hematology & Oncology

ISSN: 2162-3619

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