Fig. 1
From: Platelet desialylation and TFH cells–the novel pathway of immune thrombocytopenia
The clearance of desialylated platelets mediated by AMR and MGL. Varied mechanisms contribute to the platelet clearance. The desialylated glycoproteins (GPs) on the platelet surface can be recognized and captured by the Ashwell-Morrell receptor (AMR) of hepatocyte. Desialylated platelets from the circulation may also directly adhere to Kupffer cells. Macrophage galactose lectin (MGL) of Kupffer cells facilitates the phagocytosis and clearance of desialylated platelets through the collaboration of AMR