Fig. 1

Circulating biomarkers in DBLCL. A schematic representation of circulating biomarkers obtained through blood draw, such as circulating tumor cells (CTC), tumor-educated platelets (TEPs), cell-free DNA (cfDNA) and cell-free RNA (cfRNA). a Extracellular vesicles include exosomes, microvesicles and apoptotic bodies. Their cargo reflects the cell of origin and contains proteins, peptides, lipids, cfDNA and cfRNA. b CfRNA comprises both coding and non-coding types, including mRNA, miRNA, lncRNA and circRNA. c Figure produced using Servier Medical Art