Fig. 1
From: MicroRNA let-7b downregulates AML1-ETO oncogene expression in t(8;21) AML by targeting its 3′UTR
AML1-ETO transcripts primarily use a 3.7 kb isoform of the ETO 3′UTR in t(8;21) AML patients and cell lines. a Alignment of RNA-seq reads from healthy HSPCs (n = 2) and t(8;21) AML patient blasts (n = 4) to the final exon of ETO. Putative 3.7 kb and full-length 5.2 kb ETO 3′UTR isoforms are depicted below. b Alignment of RNA-seq reads from the t(8;21)+ Kasumi-1 and SKNO-1 cell lines to the final exon of ETO. Putative 3.7 kb and full-length 5.2 kb ETO 3′UTR isoforms are depicted below