COVID-19-associated coagulopathy: thromboembolism prophylaxis and poor prognosis in ICU

Table 3. Coagulation abnormalities/clinical prognostic factors and mortality

Prognostic factors	Survivors		Non-survivors		P value
Prognostic factors	No.	%	No.	%	P value
Temperature_max (°C)					0.291
≥39	45	25.00	51	28.33
<39	46	25.56	38	21.11
Duration of Low BP (h)					0.000*
0	83	46.11	25	13.89
<72	1	0.56	25	13.89
≥72	7	3.89	39	21.67
Blood transfusion (ml)					0.037*
0	73	40.56	55	30.56
≤800	13	7.22	20	11.11
>800	6	3.33	13	7.22
Lymphocyte					0.000*
≥1.0 × 10⁹/L	33	18.33	7	3.89
<1.0 × 10⁹/L	58	32.22	82	45.56
Platelet count					0.001*
≥150 × 10⁹/L	77	42.78	56	31.11
<150 × 10⁹/L	14	7.78	33	18.33
SIC score					0.002*
<4	85	47.22	69	38.33
≥4	6	3.33	20	11.11
DIC score					0.000*
<5	78	43.33	48	26.67
≥5	13	7.22	41	22.78
Overt DIC					0.000*
Yes	4	2.22	59	32.78
No	87	48.33	30	16.67
Prolongation of PT (s)					0.785
>3	6	3.33	5	2.78
≤3	85	47.22	84	46.67
Prolongation of aPTT (s)					0.632
>10	2	1.11	3	1.67
≤10	89	49.44	86	47.78
Fbg (g/L)					0.160
1.5–4	32	17.78	21	11.67
>4	58	32.22	65	36.11
<1.5	1	0.56	3	1.67
D-dimer (mg/L)					0.000*
≤0.5	25	13.89	1	0.56
>0.5 and ≤2	34	18.89	27	15.00
>2 and <5	13	7.22	18	10.00
>5	19	10.56	43	23.89
FDP (mg/L)					0.000*
≤5	52	28.89	10	5.56
>5 and ≤20	12	6.67	21	11.67
>20	9	5.00	34	18.89
Antithrombin (%)					0.147
≥80	20	11.11	37	20.56
<80	29	16.11	31	17.22
Serum calcium levels (mmol/L)					0.002*
≥1.8	70	38.89	73	40.56
<1.8	2	1.11	16	8.89
VTE prophylaxis					0.098
Yes	29	16.11	39	21.67
No	62	34.44	50	27.78

BP blood pressure, SIC sepsis-induced coagulopathy, DIC disseminated intravascular coagulation, PT prothrombin time, aPTT activated partial thromboplastin time, Fbg fibrinogen, FDP fibrin degradation products, VTE venous thromboembolism
Blood transfusion: red blood cells, platelet or fresh-frozen plasma
*Statistically significant

ISSN: 2162-3619