Regulation of metabolic reprogramming by tumor suppressor genes in pancreatic cancer

Liu, Mengqi; Liu, Wensheng; Qin, Yi; Xu, Xiaowu; Yu, Xianjun; Zhuo, Qifeng; Ji, Shunrong

doi:10.1186/s40164-020-00179-x

Experimental Hematology & Oncology

Table 1 The mechanisms of metabolic alteration by tumor suppressor genes in pancreatic cancer

From: Regulation of metabolic reprogramming by tumor suppressor genes in pancreatic cancer

Tumor suppressor genes	Substrates	Authors		Pathways		Cancer type/cell lines	Effects on tumor
TP53	Glucose	Matoba et al. [23]	P53-SCO2-COX		Mitochondrial respiration↓	Pancreatic cancer	Promotion
		Matoba et al. [23]	P53-SCO2-COX		Glycolysis↑	Pancreatic cancer	Promotion
		Bensaad et a. [24]		P53-TIGAR- fructose-2,6-bisphosphate	Glycolysis↑	U2OS, RKO, MCF-7	Promotion
		Butera et al. [25]		Mutant p53-GAPDH	Glycolysis↑	Pancreatic cancer	promotion
		Schwartzenberg et al. [27]		P53-GLUT1/4	Glucose transportation↓	SaOS-2, RD, C2C12	Inhibition
		Zhang et al. [28]		P53-RRAD-GLUT1	Glycolysis↓	Lung cancer	Inhibition
		Kawauchi et al. [29]		P53 mutation- NF-κB- GLUT3	Glycolysis↑	MEFs	Promotion
		Kim et al. [30]		P53-miR-34a-HK1/2, G6PI	Glycolysis↓	Pancreatic cancer	Inhibition
		Romain et al. [33]		P53 mutation-MCT1	Lactate export↑	SiHa, HeLa, MCF-7, MDA-MB-231, HCT116	Promotion
		Kim et al. [38]		P53-PUMA-MPC	Pyruvate uptake ↓ Glycolysis↑	Hepatocellular carcinoma	promotion
	Glutamine	Suzuki et al. [34]		P53-GLS2	ROS↓ GSH↓	Hepatocellular carcinoma	Inhibition
		Tran et al. [35]		mutant p53- CDKN1A	Cell cycle arrest Cell survival↑	Lymphoma	Promotion
		Tajan et al. [36]		P53-Slc1a3	Adaptation to glutamine deprivation↑	HCT116	Promotion
		Lowman et al. [37]		P53- Slc7a3-mTORC1	Adaptation to glutamine deprivation↑	MEFs	Promotion
CDKN2A	Glucose	Ju et al. [41]		p16 loss-Rb-E2F-NOX4	NADH oxidation ↑ Glycolysis↑	Pancreatic cancer	Promotion
	Glucose	Aharon et al. [42]		Aldob/Gck	Glucose uptake↑ Glycolysis rates↑	Pancreatic beta cells	Promotion
	Glutamine	-		-	-		-
SMAD4	Glucose	Raychaudhuri et al. [45]		miR-29a/ miR-23a-SMAD4	Glucose transport↓	Skeletal muscle	-
	Glucose	Liang et al. [19]		SMAD4 loss-PGK1	Glycolysis↑	Pancreatic cancer	Promotion
	Glutamine	–		–	–		–
RB	Glucose	Beemer et al. [50]		RB-E2F-Myc-HK2/LDH	Glycolysis ↓	Retinoblastoma	Inhibition
		Zhu et al. [53]		RB loss-RAS- PFKFB3- F2,6P2- PFK-1	Glycolysis↑	Gastric Cancer	Promotion
		Hsieh et al. [54]		RB loss-E2F-PDK4	Glucose uptake↑	Myoblasts, fibroblasts	Promotion
	Glutamine	Reynolds et al. [55]		RB loss-ASCT2/ GLS1	Glutamine uptake↑	MEFs	Promotion
PTEN	Glucose	Maehama et al. [61]		PTEN-PI3K/Akt- HK2/PFK	Glycolysis ↓	Human 293 cells	Inhibition
		Garcia-Cao et al. [64]		PTEN-PI3K/Akt-mTORC-PK	Glycolysis ↓	MEFs	Inhibition
		Martin et al. [62]		PTEN loss-pERK	Glycolysis↑	Prostate cancer	Promotion
		Shinde et al. [63]		PTEN-SNX27-GLUT1	Glucose transport↓	HeLa, HepG2	Inhibition
	Glutamine	Garcia-Cao et al. [64]		PTEN- APC/Cdh1- GLS1	Glutaminolysis↓	MEFs	Inhibition
FBW7	Glucose	Ji et al. [71]		FBW7- c-Myc/TXNIP	Glycolysis ↓	Pancreatic cancer	Inhibition
	Glucose	Davis et al. [72]		FBW7 mutations- Mitochondrial Gene (ATP5B/CS et al.)	Oxidative phosphorylation↑ Anabolic metabolism↑	colorectal cancer	Inhibition
	Glutamine	–		–	–		–
LKB1	Glucose	Zeng et al. [81]		LKB1loss-c-Myc-HK2	Glucose consumption ↑ Glycolysis↑	Cervical cancer	Promotion
		Dupuy et al. [82]		LKB1 loss-Akt/m TORC	Glycosis↑	Breast cancer	Promotion
		Faubert et al. [83]		LKB1 loss- HIF-1α	Glycosis↑	Lung cancer	Promotion
	Glutamine	Faubert et al. [83]		LKB1 loss- HIF-1α	Glutaminolysis↑	Lung cancer	Promotion
	Glutamine	Galan-Cobo et al. [86]		LKB1 loss- KEAP1/NRF2	Energetic and redox homeostasis	Lung cancer	Promotion
BAP1	Glucose	Bononi et al. [90]		BAP1 mutation	Glycolysis↑ Mitochondrial respiration ↓	primary fibroblasts, human mesothelial cells	promotion
		Ruan et al. [91]		BAP1-PGC1α	Gluconeogenesis↑	Mouse liver cells	–
		Baughman et al. [92]		BAP1 loss- mitochondria related proteins	Mitochondria↓	liver and pancreas	–
	Glutamine	–		–	–		–

Back to article page

ISSN: 2162-3619

Contact us

Submission enquiries: journalsubmissions@springernature.com