Table 1 Biomarkers for CRS predication
From: Macrophage, the potential key mediator in CAR-T related CRS
Biomarkers | Grade 0–3 | Grade ≥ 4 |
|---|---|---|
Inflammatory factor | ||
 CRP | ↑ | ↑↑ |
 Ferritin | ↑ | ↑↑ |
Cytokine profile | ||
 IFN-γa,b | ↑ | ↑↑ |
 IL-6a,b | ↑ | ↑↑ |
 IL-8a,b | ↑ | ↑↑ |
 IL-10a | ↑ | ↑↑ |
 IL-15a | ↑ | ↑↑ |
 sIL2Rαb | ↑ | ↑↑ |
 sIL6Rb | ↑ | ↑↑ |
 MCP-1a,b | ↑ | ↑↑ |
 MIP-1αb | ↑ | ↑↑ |
 MIP-1βa,b | ↑ | ↑↑ |
 GM-CSFb | ↑ | ↑↑ |
 TNFRp55a | ↑ | ↑↑ |
 sgp130b | ↑ | ↑↑ |
Blood biochemistry | ||
 ALT | ↑ | ↑↑ |
 AST | ↑ | ↑↑ |
 BUN | ↑ | ↑↑ |
 LDH | ↑ | ↑↑ |
 Cr | ↑ | ↑↑ |
 Coagulation | ||
 Fibrinogen (Pediatric) | – | ↓ |
 Fibrinogen (Adult) | ↓ | ↓ |
 PT (Pediatric) | – | ↑ |
 PT (Adult) | ↑ | ↑ |
 APTT (Pediatric) | – | ↑ |
 APTT (Adult) | – | – |