Fig. 5
IL-6 knockdown in ssCART-19 cells reduce the IL-6 release in vivo. a Serum levels of IL-6 and b IFN-γ in the peripheral blood of mice treated with regular CART-19 cells or ssCART-19 cells. Blood was taken on day 3 (1 day before CART-19 cell administration) and day 9 (5 days after CART-19 cell administration). c Total T cells count and d Total CAR + T cells count in the peripheral blood of mice treated with regular CART-19 cells, ssCART-19 cells, untransduced T cells, or freezing medium measured by flow cytometry