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Table 5 Factors of affecting 5-year cumulative survival rate between MSD and AD

From: Alternative donor peripheral blood stem cell transplantation for the treatment of high-risk refractory and/or relapsed childhood acute leukemia: a randomized trial

Variables

5-year cumulative OS

5-year cumulative DFS

MSD

AD

MSD

AD

Grade II-IV aGVHD

 Yes

50.0 ± 35.4

30.0 ± 17.5

50.0 ± 35.4

15.0 ± 13.8

 No

54.4. ± 9.0

78.1 ± 6.7

44.4 ± 9.3

73.6 ± 7.1

 P-value

0.474

0.002

0.605

0.001

Donor-recipient ABO compatibility

 Compatible

66.6 ± 12.8

55.6 ± 11.4

67.0 ± 12.8

50.9 ± 11.6

 Incompatible

45.9 ± 11.3

83.0. ± 7.1

27.7 ± 10.9

74.9. ± 8.5

 P-value

0.244

0.047

0.041

0.078

Conditioning regimen

 Bu/Cy-based

52.3 ± 10.3

77.6 ± 7.1

44.1 ± 10.4*

69.2 ± 7.9*

 TBI/Cy-based

60.8 ± 15.8

58.7. ± 13.1

40.5 ± 19.6*

58.7 ± 13.1*

 P-value

0.777

0.023

0.854

0.093

CMV infection

 Yes

44.4 ± 18.9

60.9 ± 9.5

15.6 ± 14.2*

57.4 ± 9.7*

 No

57.2 ± 9.7

85.0. ± 8.2

54 ± 9.8*

75 ± 9.9*

 P-value

0.748

0.033

0.235

0.083

  1. * Estimated value censored