Fig. 1

High-throughput screen identifies dacinostat and quisinostat that reduce cell viability of Daoy and D283 cells. a 125 compounds were assayed for their IC₅₀ values after the screening of 12,800 compounds. Blue bars represent the concentration range interrogated and black points indicate the IC₅₀ value derived from the curve fit. The red line represents the 1 μM IC₅₀ cutoff used to identify the 46 most potent compounds. Compounds having names too long to fit on the plot axis are identified by their compound identifier; their names are as follows: SJ000831486-1 = BML285 (diaminoquinazoline); SJ000287267-1 = cephaeline dihydrochloride heptahydrate; SJ000311301-2 = NA; SJ000312176-2 = aurora kinase/CDK inhibitor; SJ000287062-3 = 1-benzyloxycarbonylaminophenethyl chloromethyl ketone; SJ000287130-1 = lysyltryptophanyl-lysine acetate. Cmpd Conc, compound concentration. b, c The dose response curves (based on MTT assays) for cell viability of Daoy and D283 cells after treated with dacinostat and quisinostat for 48 h at the indicated concentrations