Table 3 Predictive performance of the number of positive markers for every threshold from 1 to 32 positive markers in DRE and FV DNAs

1of32

DRE

'36/36

1

(1.00, 1.00)

'5/49

0.1

(0.02, 0.19)

0.45

1

FV

'30/30

1

(1.00, 1.00)

'2/35

0.06

(− 0.02, 0.13)

0.48

1

2of32

DRE

'36/36

1

(1.00, 1.00)

'9/49

0.18

(0.08, 0.29)

0.47

1

FV

'30/30

1

(1.00, 1.00)

'5/35

0.14

(0.03, 0.26)

0.5

1

3of32

DRE

'36/36

1

(1.00, 1.00)

'14/49

0.29

(0.16, 0.41)

0.5

1

FV

'30/30

1

(1.00, 1.00)

'7/35

0.2

(0.07, 0.33)

0.52

1

4of32

DRE

'34/36

0.94

(0.87, 1.02)

'14/49

0.29

(0.16, 0.41)

0.49

0.87

FV

'30/30

1

(1.00, 1.00)

'9/35

0.26

(0.11, 0.40)

0.54

1

5of32

DRE

'34/36

0.94

(0.87, 1.02)

'19/49

0.39

(0.25, 0.52)

0.53

0.9

FV

'30/30

1

(1.00, 1.00)

'13/35

0.37

(0.21, 0.53)

0.57

1

6of32

DRE

'34/36

0.94

(0.87, 1.02)

'27/49

0.55

(0.41, 0.69)

0.6

0.93

FV

'30/30

1

(1.00, 1.00)

'16/35

0.46

(0.29, 0.62)

0.61

1

7of32

DRE

'33/36

0.92

(0.83, 1.01)

'29/49

0.59

(0.45, 0.73)

0.62

0.91

FV

'29/30

0.97

(0.90, 1.03)

'18/35

0.51

(0.35, 0.68)

0.63

0.95

8of32

DRE

'32/36

0.89

(0.79, 0.99)

'32/49

0.65

(0.52, 0.79)

0.65

0.89

FV

'28/30

0.93

(0.84, 1.02)

'23/35

0.66

(0.50, 0.81)

0.7

0.92

9of32

DRE

'30/36

0.83

(0.71, 0.96)

'33/49

0.67

(0.54, 0.80)

0.65

0.84

FV

'28/30

0.93

(0.84, 1.02)

'25/35

0.71

(0.56, 0.86)

0.73

0.92

10of32

DRE

'29/36

0.81

(0.68, 0.93)

'37/49

0.76

(0.63, 0.88)

0.71

0.85

FV

'28/30

0.93

(0.84, 1.02)

'27/35

0.77

(0.63, 0.91)

0.77

0.93

11of32

DRE

'29/36

0.81

(0.68, 0.93)

'38/49

0.78

(0.66, 0.89)

0.73

0.85

FV

'26/30

0.87

(0.75, 0.99)

'28/35

0.8

(0.67, 0.93)

0.79

0.88

12of32

DRE

'28/36

0.78

(0.64, 0.91)

'40/49

0.82

(0.71, 0.92)

0.76

0.84

FV

'24/30

0.8

(0.66, 0.94)

'30/35

0.86

(0.74, 0.97)

0.83

0.83

13of32

DRE

'26/36

0.72

(0.58, 0.87)

'41/49

0.84

(0.73, 0.94)

0.77

0.81

FV

'23/30

0.77

(0.62, 0.92)

'30/35

0.86

(0.74, 0.97)

0.82

0.81

14of32

DRE

'24/36

0.67

(0.51, 0.82)

'44/49

0.9

(0.81, 0.98)

0.83

0.79

FV

'23/30

0.77

(0.62, 0.92)

'31/35

0.89

(0.78, 0.99)

0.86

0.82

15of32

DRE

'22/36

0.61

(0.45, 0.77)

'47/49

0.96

(0.90, 1.01)

0.92

0.77

FV

'19/30

0.63

(0.46, 0.81)

'32/35

0.91

(0.82, 1.01)

0.86

0.74

16of32

DRE

'20/36

0.56

(0.39, 0.72)

'47/49

0.96

(0.90, 1.01)

0.91

0.75

FV

'15/30

0.5

(0.32, 0.68)

'34/35

0.97

(0.92, 1.03)

0.93

0.69

17of32

DRE

'17/36

0.47

(0.31, 0.64)

'48/49

0.98

(0.94, 1.02)

0.94

0.72

FV

'13/30

0.43

(0.26, 0.61)

'34/35

0.97

(0.92, 1.03)

0.92

0.67

18of32

DRE

'12/36

0.33

(0.18, 0.49)

'49/49

1

(1.00, 1.00)

1

0.67

FV

'13/30

0.43

(0.26, 0.61)

'34/35

0.97

(0.92, 1.03)

0.92

0.67

19of32

DRE

'10/36

0.28

(0.13, 0.42)

'49/49

1

(1.00, 1.00)

1

0.66

FV

'12/30

0.4

(0.22, 0.58)

'35/35

1

(1.00, 1.00)

1

0.66

20of32

DRE

'9/36

0.25

(0.11, 0.39)

'49/49

1

(1.00, 1.00)

1

0.65

FV

'8/30

0.27

(0.11, 0.42)

'35/35

1

(1.00, 1.00)

1

0.62

21of32

DRE

'8/36

0.22

(0.09, 0.36)

'49/49

1

(1.00, 1.00)

1

0.64

FV

'7/30

0.23

(0.08, 0.38)

'35/35

1

(1.00, 1.00)

1

0.6

22of32

DRE

'8/36

0.22

(0.09, 0.36)

'49/49

1

(1.00, 1.00)

1

0.64

FV

'5/30

0.17

(0.03, 0.30)

'35/35

1

(1.00, 1.00)

1

0.59

23of32

DRE

'7/36

0.19

(0.07, 0.32)

'49/49

1

(1.00, 1.00)

1

0.63

FV

'5/30

0.17

(0.03, 0.30)

'35/35

1

(1.00, 1.00)

1

0.59

24of32

DRE

'7/36

0.19

(0.07, 0.32)

'49/49

1

(1.00, 1.00)

1

0.63

FV

'3/30

0.1

(− 0.01, 0.21)

'35/35

1

(1.00, 1.00)

1

0.57

25of32

DRE

'7/36

0.19

(0.07, 0.32)

'49/49

1

(1.00, 1.00)

1

0.63

FV

'2/30

0.07

(− 0.02, 0.16)

'35/35

1

(1.00, 1.00)

1

0.56

26of32

DRE

'7/36

0.19

(0.07, 0.32)

'49/49

1

(1.00, 1.00)

1

0.63

FV

'2/30

0.07

(− 0.02, 0.16)

'35/35

1

(1.00, 1.00)

1

0.56

27of32

DRE

'3/36

0.08

(− 0.01, 0.17)

'49/49

1

(1.00, 1.00)

1

0.6

FV

'2/30

0.07

(− 0.02, 0.16)

'35/35

1

(1.00, 1.00)

1

0.56

28of32

DRE

'2/36

0.06

(− 0.02, 0.13)

'49/49

1

(1.00, 1.00)

1

0.59

FV

'2/30

0.07

(− 0.02, 0.16)

'35/35

1

(1.00, 1.00)

1

0.56

29of32

DRE

'2/36

0.06

(− 0.02, 0.13)

'49/49

1

(1.00, 1.00)

1

0.59

FV

'2/30

0.07

(− 0.02, 0.16)

'35/35

1

(1.00, 1.00)

1

0.56

30of32

DRE

'2/36

0.06

(− 0.02, 0.13)

'49/49

1

(1.00, 1.00)

1

0.59

FV

'2/30

0.07

(− 0.02, 0.16)

'35/35

1

(1.00, 1.00)

1

0.56

31of32

DRE

'1/36

0.03

(− 0.03, 0.08)

'49/49

1

(1.00, 1.00)

1

0.59

FV

'2/30

0.07

(− 0.02, 0.16)

'35/35

1

(1.00, 1.00)

1

0.56

32of32

DRE

'0/36

0

(0.00, 0.00)

'49/49

1

(1.00, 1.00)

na

0.58

FV

'0/30

0

(0.00, 0.00)

'35/35

1

(1.00, 1.00)

na

0.54