- * The P value was calculated by the Friedman test for all markers considering data obtained in three time points (weeks 0, 6 and 12), except in the cases of IL-17 and the inflammatory marker CRP, for which the measurements from the first and last time points were compared by the Wilcoxon matched-pairs signed rank test
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aNormal plasma values for IL-1β, IL-4, IL-6, IL-8, IL-10, IL-17, IFN-γ, TNF-α, sICAM1, sVCAM1, sP-Selectin, sE-Selectin, CXCL1, CXCL9, CXCL10, and CXCL12 were obtained from 10-54 healthy donors for each ELISA kit by the manufacturer (http://www.rndsystems.com). CRP blood concentration was measured by high-sensitivity nephelometry, and normal reference values were described in the National Health and Nutrition Examination Survey (NHANES) [28]
