Skip to main content

Table 3 Methotrexate effect on cytokines, adhesion molecules, chemokines and CRP

From: Low-dose methotrexate in sickle-cell disease: a pilot study with rationale borrowed from rheumatoid arthritis

  1. * The P value was calculated by the Friedman test for all markers considering data obtained in three time points (weeks 0, 6 and 12), except in the cases of IL-17 and the inflammatory marker CRP, for which the measurements from the first and last time points were compared by the Wilcoxon matched-pairs signed rank test
  2. aNormal plasma values for IL-1β, IL-4, IL-6, IL-8, IL-10, IL-17, IFN-γ, TNF-α, sICAM1, sVCAM1, sP-Selectin, sE-Selectin, CXCL1, CXCL9, CXCL10, and CXCL12 were obtained from 10-54 healthy donors for each ELISA kit by the manufacturer ( CRP blood concentration was measured by high-sensitivity nephelometry, and normal reference values were described in the National Health and Nutrition Examination Survey (NHANES) [28]