Fig. 1

a Diagnostic imaging from September 2013, 2 cm left lower lobe lesion, multilevel mediastinal involvement, and numerous hypermetabolic skeletal lesions. b May 2014 PET-CT demonstrating new hypermetabolic lesion at T12. c January 2015 attempted CT guided biopsy of T12 lesion. d August 2015 PET-CT demonstrating response to third generation TKI following identification of EGFR resistance mutation