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Fig. 1 | Experimental Hematology & Oncology

Fig. 1

From: Deregulated expression of the HSP40 family members Auxilin-1 and -2 is indicative of proteostasis imbalance and predicts patient outcome in Ph+ leukemia

Fig. 1

Heat shock protein members are differentially expressed in Ph+ leukemia. Gene expression profiling of CML patient samples in chronic phase and blast crisis. Highlighted are two homologues Auxilin-2 and Auxilin-1 (GEO accession number GSE4170) (a). In the same microarray (GEO accession number GSE4170) showed in Fig. 1a, CML patients were separated depending on their disease stage and the gene expression of Auxilin-1 and Auxilin-2 are shown after log2 transformation (b). The expression of Auxilin-1 and Auxilin-2 is shown for different ALL subsets carrying either BCR-ABL1, TEL-AML1, MLLr or TCF3-PBX1 lesions compared to CD19+ B-cells from healthy donors (http://www.stjuderesearch.org/site/data/ALL3/) (c). The mRNA levels of Auxilin-1 and Auxilin-2 were measured by qRT-PCR in primary cases of different hematological malignancies including ALL, Essential Thrombocythemia (ET), Polycythemia Vera (PV) compared to B-cell Non-Hodgkin Lymphoma (B-NHL) (d). Similarly, the mRNA levels of Auxilin-1 and Auxilin-2 were measured by qRT-PCR (used primers are shown in Table S2) in ALL and CML cell lines with different oncogenic lesions (e)

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Experimental Hematology & Oncology

ISSN: 2162-3619

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