Fig. 4
From: miR-199b, a novel tumor suppressor miRNA in acute myeloid leukemia with prognostic implications
HDAC inhibitors restore miR-199b-5p expression in THP-1 cells to induce apoptosis. a miR-199b expression in THP-1 cells upon 24 h treatment with vehicle (DMSO), Decitabine (DB, 5uM), AR-42 (2uM), or Panobinostat (0.7uM) ****p < 0.0001. b Western blot for THP-1 cells treated with DMSO [27], Panobinostat [28] or AR-42 [29] blotted for acetylated (Ac) and total histones H2A, H2B, H3 and H4. c Apoptosis via Annexin V staining for the AR-42 and Panobinostat treated cells compared to DMSO treatment