Kaplan-Meier plots of progression-free survival by MIPI risk group. (A) Low-risk group, (B) intermediate-risk group, and (C) high-risk group. Log-rank P values given for temsirolimus versus investigator’s choice of therapy. Statistical analyses shown are for illustrative purposes; the phase III trial was not powered to detect differences in progression-free survival for subsets by MIPI risk categories. MIPI = Mantle Cell Lymphoma International Prognostic Index; TEMSR 25 mg = temsirolimus 25 mg administered once weekly after three weekly doses of 175 mg; TEMSR 75 mg = temsirolimus 75 mg administered once weekly after three weekly doses of 175 mg.