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Figure 1 | Experimental Hematology & Oncology

Figure 1

From: Immunohistochemical analysis indicates that the anatomical location of B-cell non-Hodgkin’s lymphoma is determined by differentially expressed chemokine receptors, sphingosine-1-phosphate receptors and integrins

Figure 1

The role of adhesion molecules, chemokines and S1P in lymphocyte entry, egress and retention. (A) B-cell migration into lymph nodes via high endothelial venules (HEVs) is achieved through a multistep adhesion process involving rolling, sticking, crawling and finally transmigration. (B). Movement towards the chemokine CCL21 into nodes is dependent on the integrin αLβ2 binding to ICAM-1 on the HEV. (C) Once in the node B cells move in the direction of the highest concentration of chemokine/S1P. Movement towards the B zone of the nodes is dependent on the chemokine CXCL13 and/or α4β1. The direction of movement is shown here as a linear track, however cells within the lymph node go on a ‘random walk’ visiting the B and T cell zones multiple times in the search for antigen before exiting through the lymphatic sinuses in a S1PR1 dependent manner independently of integrin engagement.

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Experimental Hematology & Oncology

ISSN: 2162-3619

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