Figure 2From: Long-term survival in a patient with progressive multifocal leukoencephalopathy after therapy with rituximab, fludarabine and cyclophosphamide for chronic lymphocytic leukemia Histological examination. A: Infiltration of the brain tissue by foamy macrophages and mature lymphocytes with perivascular clustering. B: Immunohistochemical staining for neurofilaments revealed a loss of myelin. Compare affected tissue at the bottom with normal brain tissue at the upper corner of the picture. C: Reactive astrocytes with polymorphic nuclei and prominent nucleoli.Back to article page