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Table 1 Inhibition of procoagulant activity with clotting time

From: Comparative study of the effect of rivaroxaban and fondaparinux on monocyte’s coagulant activity and cytokine release

 

Rivaroxaban (μg/ml)

Fondaparinux (μg/ml)

0.15

0.25

0.35

0.5

1.0

1.5

Activated monocytes

30 ± 3*

16 ± 4*

12 ± 2*

105 ± 4

100 ± 6

105 ± 4

Activated THP-1

42 ± 2*

24 ± 3*

15 ± 1*

103 ± 7

102 ± 7

105 ± 8

  1. Percent inhibition by two drugs of procoagulant activity was measured with clotting time assay compared to controls without drugs (100%). Mean ± SEM from 5 independent experiments. 100% was the prothrombinase generated by thromboplastin diluted 1/500 added to normal plasma. *p<0.05.
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Experimental Hematology & Oncology

ISSN: 2162-3619

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