Figure 6
From: Childhood B-acute lymphoblastic leukemia: a genetic update
Evaluation of an 18 year-old female with B-ALL. A. Variably cellular marrow (100×) with clusters of B-lymphoblasts and reduced multilineage hematopoiesis. B. Representative flow cytometry histogram. The CD45(dim) gated population comprised approximately 4% of total cells and contained no excess blasts. C. Abnormal female karyotype demonstrating t(17;19) translocation. D. FISH analysis detected an abnormal signal pattern compatible with TCF3 (19p13) rearrangement.