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Figure 4 | Experimental Hematology & Oncology

Figure 4

From: Overcoming bortezomib resistance in human B cells by anti-CD20/rituximab-mediated complement-dependent cytotoxicity and epoxyketone-based irreversible proteasome inhibitors

Figure 4

Expression of B cell surface markers CD19 and CD20 on JY/WT cells and BTZ-resistant variants. (A) Percentage CD19-positive JY/WT cells and BTZ-resistant variants. (B) Expression of CD19 in BTZ-resistant JY cells relative to JY/WT cells. Results are depicted as relative Mean Fluorescence Index (MFI) and represent the mean ± SEM of 5 separate experiments. (C) Representative figure of CD19 expression in JY/WT cells and BTZ-resistant variants. Percentages and mean fluorescence intensity are indicated in the upper left quadrant. (D) Percentage CD20-positive JY/WT cells and BTZ-resistant variants. (E) Expression of CD20 in BTZ-resistant JY cells relative to JY/WT cells. Results depicted are depicted as relative Mean Fluorescence Index (MFI) and represent the mean ± SEM of 9 separate experiments. (F) Representative figure of CD20 expression in JY/WT cells and BTZ-resistant variants. Percentages and mean fluorescence intensity are indicated in the upper left quadrant. *** p < 0.001, ** p < 0.01, * p < 0.05.

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