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Table 1 Immunogenetic characteristics (HLA and KIR genotypes)

From: Molecular monitoring of minimal residual disease in two patients with MLL-rearranged acute myeloid leukemia and haploidentical transplantation after relapse

 

Recipient HLA

Donor HLA

Recipient KIR

Donor KIR

case 1

A*0101, A*0301,

B*1801, B*4101, Cw*0102, Cw*1701, DRB1*0301, DRB1*1301, DQB1*0201, DQB1*0603

A*0101, A*2902,

B*1801, B*4403, Cw*0102, Cw*1601, DRB1*0301, DRB1*0701, DQB1*0201, DQB1*0202

2DL1+, 2DL2+, 2DL3-, 2DL4+, 2DL5+, 2DP1+, 2DS1 +, 2DS2+, 2DS3+, 2DS4-, 2DS5-, 3DL1+, 3DL2+, 3DL3+, 3DP1+, 3DS1+ (2DS4 could not be excluded).

2DL1+, 2DL2+, 2DL3+, 2DL4+, 2DL5-, 2DP1+, 2DS1-, 2DS2+, 2DS3-, 2DS4+, 2DS5-, 3DL1+, 3DL2+, 3DL3+, 3DP1+, 3DS1+

case 2

A*0201, A*2601,

B*4403, B*5701, Cw*0401, Cw*0602, DRB1*0402, DRB1*0701, DQB1*0201, DQB1*0302

A*0201, A*6801,

B*1302, B*4402,

Cw*0501, Cw*0602, DRB1*0401, DRB1*0701, DQB1*0201, DQB1*0301

2DL1+, 2DL2-, 2DL3+, 2DL4+, 2DL5+, 2DP1+, 2DS1+, 2DS2-, 2DS3-, 2DS4+, 2DS5+, 3DL1+, 3DL2+, 3DL3+, 3DP1+, 3DS1+

2DL1+, 2DL2-, 2DL3+, 2DL4+, 2DL5+, 2DP1+, 2DS1+, 2DS2-, 2DS3-, 2DS4+, 2DS5+, 3DL1+, 3DL2+, 3DL3+, 3DP1+, 3DS1+

  1. Patient 2 was serologically HLA-haploidentical to her donor. However, high resolution DNA typing and HLA typing of the patient’s father revealed that donor and patient had inherited different HLA haplotypes from their parents and were coincidentially nearly haploidentical (haploidentity apart from one molecular B44 mismatch).
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Experimental Hematology & Oncology

ISSN: 2162-3619

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