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  1. Breast cancer is the most common malignancy and the second leading cause of cancer-related death in women. Recent studies have indicated that aberrant activation of Rho GTPases relates to the malignant propert...

    Authors: Ming Yi, Di Zhang, Bin Song, Bin Zhao, Mengke Niu, Yuze Wu, Zhijun Dai and Kongming Wu
    Citation: Experimental Hematology & Oncology 2022 11:107
    Content type: Research Published on:

  3. Brain metastasis accounts for a large number of cancer-related deaths. The host immune system, involved at each step of the metastatic cascade, plays an important role in both the initiation of the brain metas...

    Authors: Wei-Wei Chen, Timothy Shun Man Chu, LiangLiang Xu, Cai-Ning Zhao, Wai-Sang Poon, Gilberto Ka-Kit Leung and Feng-Ming (Spring) Kong
    Citation: Experimental Hematology & Oncology 2022 11:105
    Content type: Review Published on:

  4. Breast cancer is one the most common cause of cancer death in women worldwide. We report here the first phase II study investigating a virus genetically engineered for tumor-selective replication in patients w...

    Authors: Sophie Cousin, Maud Toulmonde, Michèle Kind, Jean-Philippe Guegan, Alban Bessede, Coralie Cantarel, Carine Bellera and Antoine Italiano
    Citation: Experimental Hematology & Oncology 2022 11:104
    Content type: Correspondence Published on:

  5. Acute promyelocytic leukemia (APL) is highly aggressive and is frequently associated with disseminated intravascular coagulation and high early death rates. Although all-trans retinoic acid (RA) induces comple...

    Authors: Xubo Gong, Piaoping Kong, Teng Yu, Xibin Xiao, Lin Wang, Yiwen Sang, Xiang Li, Bin Zhang, Zhihua Tao and Weiwei Liu
    Citation: Experimental Hematology & Oncology 2022 11:103
    Content type: Correspondence Published on:

  6. Unlike many solid tumors, epithelial ovarian cancer (EOC) has a clear metastatic predilection to the adipocyte-rich niche, especially the omentum. However, the underlying mechanism driving this process remains...

    Authors: Chen Wang, Taiyang Ye, Wenjing Wang, Keqi Song, Jie Zhu, Lan Dai and Wen Di
    Citation: Experimental Hematology & Oncology 2022 11:102
    Content type: Correspondence Published on:

  7. Programmed cell death protein 1(PD-1) is a type of immune-inhibitory checkpoint protein, which delivers inhibitory signals to cytotoxic T cells by binding to the programmed death ligand-1 (PD-L1) displayed on ...

    Authors: Mengyuan Dai, Miao Liu, Hua Yang, Can Küçük and Hua You
    Citation: Experimental Hematology & Oncology 2022 11:101
    Content type: Review Published on:

    The Publisher Correction to this article has been published in Experimental Hematology & Oncology 2022 11:106

  9. Neutrophil extracellular traps (NETs) released by activated neutrophils typically consist of DNA-histone complexes and granule proteins. NETs were originally identified as a host defense system against foreign...

    Authors: Yue Chen, Haoyue Hu, Songtao Tan, Qionglan Dong, Xue Fan, Yi Wang, Huan Zhang and Jun He
    Citation: Experimental Hematology & Oncology 2022 11:99
    Content type: Review Published on:

  10. Uterine and ovarian cancers are the most common gynecologic cancers. N6−methyladenosine (m6A), an important internal RNA modification in higher eukaryotes, has recently become a hot topic in epigenetic studies. N...

    Authors: Jiahua Chen, Bao Guo, Xiaojing Liu, Jing Zhang, Junhui Zhang, Yuan Fang, Suding Zhu, Bing Wei, Yunxia Cao and Lei Zhan
    Citation: Experimental Hematology & Oncology 2022 11:98
    Content type: Review Published on:

  11. Epithelial cell adhesion molecule (EpCAM) functions not only in physiological processes but also participates in the development and progression of cancer. In recent decades, extensive efforts have been made t...

    Authors: Yiyang Liu, Yufei Wang, Sheng Sun, Zeyu Chen, Shuai Xiang, Zeyang Ding, Zhao Huang and Bixiang Zhang
    Citation: Experimental Hematology & Oncology 2022 11:97
    Content type: Review Published on:

  12. Acute graft-versus-host disease (aGVHD), especially intestinal aGVHD, is one of the most severe complications after allogeneic hematopoietic stem cell transplantation (HSCT). Fecal microbiota transplantation (...

    Authors: Yin Liu, Ye Zhao, Jiaqian Qi, Xiao Ma, Xiaofei Qi, Depei Wu and Yang Xu
    Citation: Experimental Hematology & Oncology 2022 11:96
    Content type: Correspondence Published on:

  13. Vitreoretinal lymphoma (VRL) is strongly linked to central nervous system (CNS) progression with no standard treatment approaches. Commonly used strategies include repeated intraocular injections of low-dose m...

    Authors: Wenxue Guan, Liang Wang and Xiaoyan Peng
    Citation: Experimental Hematology & Oncology 2022 11:95
    Content type: Correspondence Published on:

  14. While numerous targeted therapies have been recently adopted to improve the treatment of hematologic malignancies, acquired or intrinsic resistance poses a significant obstacle to their efficacy. Thus, there i...

    Authors: Gus O. Nwosu, Jason A. Powell and Stuart M. Pitson
    Citation: Experimental Hematology & Oncology 2022 11:94
    Content type: Review Published on:

  15. Cancer is one of the leading causes of death worldwide due to high heterogeneity. Although chemotherapy remains the mainstay of cancer therapy, non-selective toxicity and drug resistance of mono-chemotherapy i...

    Authors: Mo Wu, Wei Huang, Nan Yang and Yanyong Liu
    Citation: Experimental Hematology & Oncology 2022 11:93
    Content type: Review Published on:

  16. Though circular RNAs (circRNAs) are the key regulators in tumor carcinogenesis, they remain largely unexplored in hepatocellular carcinoma (HCC).

    Authors: Xia-Hui Lin, Zhi-Yong Liu, Dan-Ying Zhang, Si Zhang, Wen-Qing Tang, Dong-Ping Li, Feng Zhang, Rong-Xin Chen, Shu-Qiang Weng, Ru-Yi Xue and Ling Dong
    Citation: Experimental Hematology & Oncology 2022 11:92
    Content type: Research Published on:

  17. RHO GTPases are a subfamily of the RAS superfamily of proteins, which are highly conserved in eukaryotic species and have important biological functions, including actin cytoskeleton reorganization, cell proli...

    Authors: Tiantian Wang, Dean Rao, Chengpeng Yu, Jiaqi Sheng, Yiming Luo, Limin Xia and Wenjie Huang
    Citation: Experimental Hematology & Oncology 2022 11:91
    Content type: Review Published on:

  19. Aberrant DNA methylation (DNAm) is an important epigenetic regulator in various cancers. Pan-cancer DNAm analyses have investigated the potential common mechanisms of DNAm in tumorigenesis. However, these pan-...

    Authors: Zheng Dong and Hongyu Zhou
    Citation: Experimental Hematology & Oncology 2022 11:89
    Content type: Correspondence Published on:

  20. Accumulating evidence implicates that gut fungi are associated with the pathogenesis of colorectal cancer (CRC). Our previous study has revealed that Candida tropicalis (C. tropicalis) promotes colorectal tumorig...

    Authors: Zhiyong Zhang, Yaojun Zheng, Ying Chen, Yuxin Yin, Yuxi Chen, Qianyu Chen, Yayi Hou, Sunan Shen, Mingming Lv and Tingting Wang
    Citation: Experimental Hematology & Oncology 2022 11:88
    Content type: Research Published on:

  21. Pseudogenes play an essential role in tumor occurrence and progression. However, the functions and mechanisms of pseudogenes in clear cell renal cell carcinoma (ccRCC) remain largely elusive.

    Authors: Lei Yang, Haoli Yin, Yi Chen, Chun Pan, Hexing Hang, Yanwen Lu, Wenliang Ma, Xin Li, Weidong Gan, Hongqian Guo and Dongmei Li
    Citation: Experimental Hematology & Oncology 2022 11:87
    Content type: Research Published on:

  22. Acute lymphoblastic leukemia is the most common childhood malignancy. One of the drugs used in the treatment is Asparaginase, and monitoring of its activity levels enables better outcomes. Since 2018, our labo...

    Authors: Daiane Keller Cecconello, Ciliana Rechenmacher, Klerize Anecely de Souza Silva, Fernanda Fetter Scherer, Thomas Dal Bem Prates, Rebeca Ferreira Marques, Liane Esteves Daudt and Mariana Bohns Michalowski
    Citation: Experimental Hematology & Oncology 2022 11:86
    Content type: Correspondence Published on:

  23. Chimeric antigen receptor (CAR)-engineered T (CAR-T) cells have obtained prominent achievement in the clinical immunotherapy of hematological malignant tumors, leading to a rapid development of cellular immuno...

    Authors: Xiao Wang, Xuejiao Yang, Xiang Yuan, Wenbo Wang and Yueying Wang
    Citation: Experimental Hematology & Oncology 2022 11:85
    Content type: Review Published on:

  24. The lymphatic vascular system represents a major route for dissemination of several solid tumors, including melanoma. Even though the members of the Vascular Endothelial Growth Factor family VEGF-C and VEGF-A ...

    Authors: Marta Turati, Arianna Giacomini, Sara Rezzola, Federica Maccarinelli, Giorgia Gazzaroli, Sonia Valentino, Barbara Bottazzi, Marco Presta and Roberto Ronca
    Citation: Experimental Hematology & Oncology 2022 11:84
    Content type: Correspondence Published on:

  25. Thioredoxin-1 (TXN1) is one of the major cellular antioxidants in mammals and is involved in a wide range of physiological cellular responses. However, little is known about the roles and the underlying molecu...

    Authors: Shaima Jabbar, Parker Mathews, Xiaobei Wang, Pasupathi Sundaramoorthy, Emily Chu, Sadhna O. Piryani, Shengli Ding, Xiling Shen, Phuong L. Doan and Yubin Kang
    Citation: Experimental Hematology & Oncology 2022 11:83
    Content type: Research Published on:

  26. Since U.S. President Barack Obama announced the Precision Medicine Initiative in his New Year’s State of the Union address in 2015, the establishment of a precision medicine system has been emphasized worldwid...

    Authors: Ryuji Hamamoto, Takafumi Koyama, Nobuji Kouno, Tomohiro Yasuda, Shuntaro Yui, Kazuki Sudo, Makoto Hirata, Kuniko Sunami, Takashi Kubo, Ken Takasawa, Satoshi Takahashi, Hidenori Machino, Kazuma Kobayashi, Ken Asada, Masaaki Komatsu, Syuzo Kaneko…
    Citation: Experimental Hematology & Oncology 2022 11:82
    Content type: Review Published on:

  27. The bone marrow microenvironment of acute myeloid leukemia (AML) consists of various cell types and signaling factors, which serve as a niche supporting leukemia cells in their invasion of the human body. Howe...

    Authors: Binyan Xu, Ziying Zhou, Yueting Wen, Zhongwei Li, Zhongxi Huang and Yuhua Li
    Citation: Experimental Hematology & Oncology 2022 11:81
    Content type: Correspondence Published on:

  28. RNA binding proteins (RBPs) have recently emerged as important post-transcriptional gene expression regulators in both normal development and disease. RBPs influence the fate of mRNAs through multiple mechanis...

    Authors: Tiffany M. Tran and Dinesh S. Rao
    Citation: Experimental Hematology & Oncology 2022 11:80
    Content type: Review Published on:

  29. Cancer-associated thrombosis (CAT) poses a significant disease burden and the incidence in Asian populations is increasing. Anticoagulation is the cornerstone of treatment, but can be challenging due to the hi...

    Authors: Lai Heng Lee, Pongwut Danchaivijitr, Noppacharn Uaprasert, Harinder Gill, Dennis Lee Sacdalan, Gwo Fuang Ho, Rajiv Parakh, Paresh Pai, Jen-Kuang Lee, Nannette Rey and Alexander T. Cohen
    Citation: Experimental Hematology & Oncology 2022 11:79
    Content type: Review Published on:

  30. Camrelizumab (SHR-1210) is a humanized IgG4 monoclonal anti-programmed cell death protein 1 (PD-1) antibody that has been shown to inhibit the binding of PD-1 to PD-L1, thereby blocking the immune escape of va...

    Authors: Rong Ma, Jia-Lin Wang and Yan-Yang Wang
    Citation: Experimental Hematology & Oncology 2022 11:78
    Content type: Correspondence Published on:

  31. Glucose-6-phosphate dehydrogenase (G6PD) as the rate-limiting enzyme in the pentose phosphate pathway (PPP) is well-established as an aberrantly expressed protein in numerous clinical diseases; however, its ro...

    Authors: Rui Li, Mengying Ke, Mingming Qi, Zhenru Han, Yuhao Cao, Zhendong Deng, Jinjun Qian, Ye Yang and Chunyan Gu
    Citation: Experimental Hematology & Oncology 2022 11:77
    Content type: Research Published on:

  32. Spindle and kinetochore-associated complex subunit 3 (SKA3) is a microtubule-binding subcomplex of the outer kinetochore that is required for proper chromosomal segregation and cell division. However, little i...

    Authors: Dechao Feng, Weizhen Zhu, Xu Shi, Qiao Xiong, Dengxiong Li, Wuran Wei, Ping Han, Qiang Wei and Lu Yang
    Citation: Experimental Hematology & Oncology 2022 11:76
    Content type: Correspondence Published on:

  33. The tripartite-motif (TRIM) family represents one of the largest classes of putative single protein RING-finger E3 ubiquitin ligases. TRIM family is involved in a variety of cellular signaling transductions an...

    Authors: Ning Huang, Xiaolin Sun, Peng Li, Xin liu, Xuemei Zhang, Qian Chen and Hong Xin
    Citation: Experimental Hematology & Oncology 2022 11:75
    Content type: Review Published on:

  34. Acute myeloid leukemia (AML) is a complex, heterogeneous malignant hematologic disease. Although multiple prognostic-related genes gave been explored in previous studies, there are still many genes whose progn...

    Authors: Xueqian Li, Jiaqian Qi, Xiaofei Song, Xiaoyan Xu, Tingting Pan, Hong Wang, Jingyi Yang and Yue Han
    Citation: Experimental Hematology & Oncology 2022 11:74
    Content type: Correspondence Published on:

  35. There are considerable new data on mutation topography in persons with myelodysplastic syndromes (MDS). These data have been used to update conventional risk models such as the Revised International Prognostic...

    Authors: Junying Wu, Yudi Zhang, Tiejun Qin, Zefeng Xu, Shiqiang Qu, Lijuan Pan, Bing Li, Yujiao Jia, Chengwen Li, Huijun Wang, Qingyan Gao, Wenyu Cai, Jingye Gong, Songyang Zhao, Fuhui Li, Robert Peter Gale…
    Citation: Experimental Hematology & Oncology 2022 11:73
    Content type: Research Published on:

  36. Long-term outcome is unfavourable for relapsed/refractory (r/r) lymphoma patients who are resistant to salvage chemotherapy, even after subsequent autologous stem-cell transplantation (ASCT). Although anti-CD3...

    Authors: Peiling Zhang, Xiuxiu Yang, Yang Cao, Jue Wang, Mi Zhou, Liting Chen, Jia Wei, Zekai Mao, Di Wang, Yi Xiao, Haichuan Zhu, Shangkun Zhang, Tongcun Zhang, Yicheng Zhang, Jianfeng Zhou and Liang Huang
    Citation: Experimental Hematology & Oncology 2022 11:72
    Content type: Research Published on:

  37. Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive non-Hodgkin lymphoma, and about 10% of DLBCL cases primarily occur in the gastrointestinal tract. Previous reports have revealed that primary...

    Authors: Shan-Shan Li, Xiao-Hui Zhai, Hai-Ling Liu, Ting-Zhi Liu, Tai-Yuan Cao, Dong-Mei Chen, Le-Xin Xiao, Xiao-Qin Gan, Ke Cheng, Wan-Jia Hong, Yan Huang, Yi-Fan Lian and Jian Xiao
    Citation: Experimental Hematology & Oncology 2022 11:71
    Content type: Research Published on:

  38. Non-small cell lung cancer (NSCLC) is a heterogeneous disease, and its demarcation contributes to various therapeutic outcomes. However, a small subset of tumors shows different molecular features that are in ...

    Authors: Jie Mei, Yun Cai, Ofek Mussafi, Mingfeng Zheng, Yongrui Xu, Ruo Chen, Guanyu Jiang, Wenjun Mao, Wei Xia and Yuan Wan
    Citation: Experimental Hematology & Oncology 2022 11:70
    Content type: Correspondence Published on:

  39. Peripheral myelin protein 22 (PMP22) and epithelial membrane proteins (EMP-1, -2, and -3) belong to a small hydrophobic membrane protein subfamily, with four transmembrane structures. PMP22 and EMPs are widely...

    Authors: Nan Zhang, Hong‑Ping Zhu, Wei Huang, Xiang Wen, Xin Xie, Xian Jiang, Cheng Peng, Bo Han and Gu He
    Citation: Experimental Hematology & Oncology 2022 11:69
    Content type: Review Published on:

    The Correction to this article has been published in Experimental Hematology & Oncology 2022 11:90

  40. The protein kinase A (PKA)/cAMP response element-binding protein (CREB) has been suggested to be related to the inhibition of the proliferation of non-small cell lung cancer (NSCLC) cells. This study aimed to ...

    Authors: Jae Heun Chung, Ho Jung Choi, Yong Jung Kang, Yun Seong Kim, Sang-Yull Lee, Ryuk Jun Kwon, Han-Sol Jeong, Su-Jung Park, Yeongmu Jeong, Dongwan Kang, Jeongin Ko, SangGyun Noh, Hae Young Chung, Hyung Ryong Moon and Seong Hoon Yoon
    Citation: Experimental Hematology & Oncology 2022 11:68
    Content type: Research Published on:

  41. Relapsed/refractory acute myeloid leukemia (AML) patients generally have a dismal prognosis and the treatment remains challenging. Due to the expression of CD7 on 30% AML and not on normal myeloid and erythroi...

    Authors: Xuanqi Cao, Haiping Dai, Qingya Cui, Zheng Li, Wenhong Shen, Jinlan Pan, Hongjie Shen, Qinfen Ma, Mengyun Li, Sifan Chen, Juncheng Chen, Xiaming Zhu, Huimin Meng, Lin Yang, Depei Wu and Xiaowen Tang
    Citation: Experimental Hematology & Oncology 2022 11:67
    Content type: Correspondence Published on:

  42. Similar to neurodegenerative diseases, the concept that tumors are prion like diseases has been proposed in recent years. p53, the most well-known tumor suppressor, has been extensively studied for its express...

    Authors: Jingzhi Li, Ming Guo, Lin Chen, Zhuchu Chen, Ying Fu and Yongheng Chen
    Citation: Experimental Hematology & Oncology 2022 11:66
    Content type: Review Published on:

  43. Taxanes plus carboplatin (TP) regimen may be an acceptable alternative adjuvant chemotherapy strategy in patients with triple-negative breast cancer (TNBC); however, the difference with the anthracycline-based...

    Authors: Fangchao Zheng, Tong Wei, Xue Wang, Feng Du, Jian Yue and Peng Yuan
    Citation: Experimental Hematology & Oncology 2022 11:65
    Content type: Correspondence Published on:

  44. Fanconi anemia (FA) is a rare disease of bone marrow failure. FA patients are prone to develop myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). However, the molecular clonal evolution of the pr...

    Authors: Lixian Chang, Zejia Cui, Deyang Shi, Yajing Chu, Bichen Wang, Yang Wan, Qiuyi Ma, Ranran Zhang, Haoyuan Li, Xuelian Cheng, Tao Cheng, Xiaofan Zhu, Cheng Li and Weiping Yuan
    Citation: Experimental Hematology & Oncology 2022 11:64
    Content type: Research Published on:

  45. Immunotherapies have emerged as potential treatments for metastatic castration-resistant prostate cancer (mCRPC). However, it is still unclear to identify the efficacy and safety of immunotherapy in large-scal...

    Authors: Anqiang Zhang and Dali Tong
    Citation: Experimental Hematology & Oncology 2022 11:63
    Content type: Correspondence Published on:

  46. Increasing evidence of association between kidney stone disease (KSD) and renal cell carcinoma (RCC) has been reported. Nevertheless, mechanism underlying such association remained unknown. Herein, we investig...

    Authors: Paleerath Peerapen, Wanida Boonmark, Pattaranit Putpeerawit and Visith Thongboonkerd
    Citation: Experimental Hematology & Oncology 2022 11:62
    Content type: Correspondence Published on:

  47. Cellular immunotherapy, including the chimeric antigen receptor T (CAR-T) cell therapy and CAR- natural killer (CAR-NK) cell therapy, has undergone extensive clinical investigation and development in recent ye...

    Authors: Ji-nuo Wang, Tianning Gu, Yongxian Hu and He Huang
    Citation: Experimental Hematology & Oncology 2022 11:61
    Content type: Review Published on:

  48. Targeting B-cell receptor signalling using Bruton tyrosine kinase (BTK) inhibitors (BTKis) has become a highly successful treatment modality for B-cell malignancies, especially for chronic lymphocytic leukaemi...

    Authors: Haoran Wang, Hao Guo, Jingyi Yang, Yanyan Liu, Xingchen Liu, Qing Zhang and Keshu Zhou
    Citation: Experimental Hematology & Oncology 2022 11:60
    Content type: Review Published on:

  49. The prognosis of most thyroid cancer patients is excellent, but for those with advanced or metastatic thyroid cancer, effective treatments are still lacking. Chimeric antigen receptor (CAR) T-cell therapy has ...

    Authors: Jing Ding, Deyu Li, Xingchen Liu, Hu Hei, Baoxi Sun, Dongmin Zhou, Keshu Zhou and Yongping Song
    Citation: Experimental Hematology & Oncology 2022 11:59
    Content type: Correspondence Published on:

  50. Clonal hematopoiesis of indeterminate potential (CHIP) is associated with a small risk of developing hematologic malignancies and a higher risk of cardiovascular diseases (CVD). We asked whether the reverse co...

    Authors: Wei Qiao, Elliana Young, Chun Feng, Suyu Liu, Jeff Jin, Laila Noor, Cristhiam M. Rojas Hernandez, Gautam Borthakur, Olga Gorlova and Vahid Afshar-Kharghan
    Citation: Experimental Hematology & Oncology 2022 11:58
    Content type: Correspondence Published on:
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