Fig. 9

Cell-to-cell communication in primary and lymphatic metastatic PCa TME. (A). Cell communication network in primary and lymphatic metastatic lesions; (B). Heatmap showing cell interaction pathways in primary and lymphatic metastatic lesions identified for each cell type. (C). Bar plots of signaling axes ranking using overall information flow differences in interaction networks between primary and lymphatic metastatic lesions. Top signaling pathways with red-colored labels are more enriched in primary lesion, middle pathways with black-colored labels are equally enriched in lymphatic metastatic and primary lesions, and bottom pathways with green-colored labels are more enriched in lymphatic metastatic lesions. (D). Overall signaling patterns for each cell type in primary and lymphatic metastatic lesions