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Fig. 2 | Experimental Hematology & Oncology

Fig. 2

From: ScRNA-seq revealed an immunosuppression state and tumor microenvironment heterogeneity related to lymph node metastasis in prostate cancer

Fig. 2

Heterogeneity and CNV analysis of luminal cells; (A). Seven main luminal subgroups identified using UMAP analysis; (B). Feature plots for marker genes; Color legend shows log1p normalized gene expression levels; (C). Heatmap of average expression for top five DEGs among seven subgroups. Color legend indicates normalized gene expression levels among subgroups; (D). GSEA heatmap for 50 hallmark gene sets in MSigDB database among seven luminal subclusters; (E). Hierarchical heatmap showing large-scale CNVs in seven luminal subgroups; (F). Differential analysis heatmap of transcriptional regulators among seven luminal subgroups; (G). Luminal subgroups in primary and metastatic lesions identified using UMAP analysis; (H). Scatter plot of DEGs between primary lesion and lymphatic metastases. Top 10 DEGs are labeled in red; (I). Functional enrichment DEG analysis in primary lesion and lymphatic metastases. (J). Heatmap of activated transcription factors in lymphatic metastases and primary lesions. Red indicates high activity, and blue shows low activity

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