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Table 2 Univariate and multivariate analyses of surface-TREM2 level on M-MDSCs predicting survival in treatment-naive DLBCL patients

From: Surface TREM2 on circulating M-MDSCs as a novel prognostic factor for adults with treatment-naïve diffuse large B-cell lymphoma

Clinical factors

Progression-free survival

Overall survival

Univariate

Multivariatea,b

Univariate

Multivariatea,b

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

Age > 70

2.574 (1.210–5.473)

0.014

4.173 (1.777–9.803)

0.001

4.997 (1.667–14.975)

0.004

3.992 (1.309–12.172)

0.015

Female

1.737 (0.858–3.516)

0.125

2.420 (1.162–5.043)

0.018

1.455 (0.603–3.512)

0.404

  

IPI risk

 High risk

 Intermediate risk

 Low risk

9.060 (2.089–39.300)

3.989 (0.891–17.849)

1

0.003

0.070

  

11.362 (1.476–87.444)

4.315 (0.531–35.088)

1

0.020

0.172

  

Bulky mass > 7.5 cm

0.972 (0.466–2.031)

0.940

–

–

0.767 (0.295–1.998)

0.587

–

–

BM involvement

3.238 (1.598–6.560)

0.001

2.740 (1.280–5.865)

0.009

1.981 (0.809–4.852)

0.135

  

Non-GCB typec

1.642 (0.673–4.008)

0.276

–

–

1.516 (0.506–4.540)

0.457

–

–

Double expressor lymphoma

1.874 (0.923–3.804)

0.082

2.613 (1.233–5.539)

0.012

1.342 (0.554–3.252)

0.515

–

–

Absolute count of CD4+ T cells in peripheral blood < 506/µL

2.208 (1.054–4.624)

0.036

  

2.083 (0.829–5.233)

0.118

  

Absolute count of CD8+ T cells in peripheral blood < 390/µL

2.507 (1.179–5.331)

0.017

  

2.577 (0.989–6.714)

0.053

  

Percentage of M-MDSCs among CD45+ cells in PB > 0.92%

2.451 (1.147–5.234)

0.021

  

3.626 (1.303–10.093)

0.014

2.409 (0.843–6.889)

0.101

Normalized MFI change of surface TREM2 on M-MDSCs

 > 44%

 2–44%

 < 2%

10.681 (2.433–46.894)

4.822 (1.091–21.304)

1

0.002

0.038

8.332 (1.838–37.778)

4.425 (0.980–19.971)

0.006

0.053

13.690 (1.765–106.182)

5.014 (0.626–40.169)

1

0.012

0.129

10.300 (1.307–81.169)

4.217 (0.510–34.834)

0.027

0.182

  1. aMultivariate Cox regression model (the backward stepwise method) included all available variables with P < 0.200
  2. bAge and sex were forced into the multivariate analysis because they may confound between-subject comparisons
  3. cAccording to the Hans algorithm, by immunohistochemistry stain
  4. CI, confidence interval; DLBCL, diffuse large B-cell lymphoma; GCB, germinal center B cell; HR, hazard ratio; IPI, international prognostic index; M-MDSCs, monocytic myeloid-derived suppressor cells; TREM2, triggering receptors expressed on myeloid cells 2; PB, peripheral blood
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Experimental Hematology & Oncology

ISSN: 2162-3619

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