From: Detection of myeloma cell-derived microvesicles: a tool to monitor multiple myeloma load
AUC (95%CI) | P Value | Optimal | |||
---|---|---|---|---|---|
Cutoff Points, μL | Sensitivity, % | Specificity, % | |||
NDMM vs HDs (BM) | |||||
CD41a-Ps + | 0.9519(0.8598–0.9900) | < 0.001 | 193.20 | 99.00 | 94.44 |
Ps + CD41a-CD138 + | 0.9666(0.9275–0.9900) | < 0.001 | 73.03 | 99.00 | 85.29 |
Ps + CD41a-BCMA + | 0.9408(0.8906–0.9911) | < 0.001 | 11.78 | 90.91 | 85.29 |
Ps + CD41a-CD319 + | 0.8890(0.8119–0.9662) | < 0.001 | 44.22 | 88.64 | 85.29 |
Ps + CD41a-CD138 + BCMA + | 0.7961(0.6941–0.8981) | < 0.001 | 6.61 | 79.55 | 70.59 |
Ps + CD41a-CD138 + CD319 + | 0.7874(0.6871–0.8877) | < 0.001 | 48.67 | 65.91 | 82.35 |
Ps + CD41a-BCMA + CD319 + | 0.7059(0.5873–0.8245) | 0.002 | 11.75 | 59.09 | 79.41 |
NDMM vs HDs (PB) | |||||
CD41a-Ps + | 0.8596(0.7681–0.9511) | < 0.001 | 27.02 | 81.82 | 76.67 |
Ps + CD41a-CD138 + | 0.8636(0.7769–0.9504) | < 0.001 | 5.105 | 93.94 | 68.75 |
Ps + CD41a-BCMA + | 0.7325(0.6065–0.8584) | 0.001 | 2.365 | 87.88 | 59.38 |
Ps + CD41a-CD319 + | 0.7784(0.6643–0.8925) | < 0.001 | 5.495 | 81.82 | 71.88 |
Ps + CD41a-CD138 + BCMA + | 0.6795(0.5487–0.8102) | 0.01 | 0.890 | 59.38 | 75.76 |
Ps + CD41a-CD138 + CD319 + | 0.7476(0.6301–0.8652) | < 0.001 | 3.340 | 57.58 | 84.38 |
Ps + CD41a-BCMA + CD319 + | 0.8016(0.6946–0.9086) | < 0.001 | 2.020 | 69.70 | 84.38 |
NDMM vs CR (BM) | |||||
CD41a-Ps + | 0.7351(0.6258–0.8444) | < 0.001 | 223.60 | 89.36 | 60.00 |
Ps + CD41a-CD138 + | 0.7705(0.6689–0.8720) | < 0.001 | 101.90 | 90.91 | 57.50 |
Ps + CD41a-BCMA + | 0.7966(0.6992–0.8939) | < 0.001 | 15.70 | 86.36 | 70.00 |
Ps + CD41a-CD319 + | 0.7165(0.6070–0.8260) | < 0.001 | 104.40 | 65.91 | 70.00 |
Ps + CD41a-CD138 + BCMA + | 0.5858(0.4634–0.7082) | 0.18 | 108.30 | 20.45 | 97.50 |
Ps + CD41a-CD138 + CD319 + | 0.6463(0.5286–0.7604) | 0.02 | 102.90 | 36.36 | 95.00 |
Ps + CD41a-BCMA + CD319 + | 0.6011(0.4758–0.7237) | 0.11 | 101.3 | 34.56 | 97.00 |
NDMM vs CR (PB) | |||||
CD41a-Ps + | 0.8013(0.6917–0.9210) | < 0.001 | 25.78 | 84.85 | 74.07 |
Ps + CD41a-CD138 + | 0.7168(0.5776–0.8476) | 0.004 | 5.180 | 55.17 | 90.91 |
Ps + CD41a-BCMA + | 0.7168(0.5843–0.8494) | 0.003 | 1.720 | 51.72 | 93.94 |
Ps + CD41a-CD319 + | 0.6855(0.5465–0.8244) | 0.010 | 3.950 | 44.83 | 93.94 |
Ps + CD41a-CD138 + BCMA + | 0.6390(0.4961–0.7819) | 0.060 | 0.890 | 55.17 | 75.76 |
Ps + CD41a-CD138 + CD319 + | 0.6473(0.5098–0.7848) | 0.050 | 2.230 | 58.62 | 69.70 |
Ps + CD41a-BCMA + CD319 + | 0.7048(0.5721–0.8375) | 0.006 | 1.990 | 75.86 | 69.70 |
MRD (−) vs MRD ( +) (BM) | |||||
CD41a-Ps + | 0.9160(0.8471–0.9848) | < 0.001 | 33.22 | 72.22 | 92.31 |
Ps + CD41a-CD138 + | 0.8433(0.7427–0.9439) | < 0.001 | 22.25 | 55.65 | 84.62 |
Ps + CD41a-BCMA + | 0.8590(0.7530–0.9649) | < 0.001 | 1.165 | 98.15 | 61.54 |
Ps + CD41a-CD319 + | 0.8412(0.7436–0.9387) | < 0.001 | 6.305 | 72.22 | 92.31 |