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Table 1 The AUC values of ROC curves

From: Detection of myeloma cell-derived microvesicles: a tool to monitor multiple myeloma load

 

AUC (95%CI)

P Value

Optimal

Cutoff Points, μL

Sensitivity, %

Specificity, %

NDMM vs HDs (BM)

 CD41a-Ps + 

0.9519(0.8598–0.9900)

 < 0.001

193.20

99.00

94.44

 Ps + CD41a-CD138 + 

0.9666(0.9275–0.9900)

 < 0.001

73.03

99.00

85.29

 Ps + CD41a-BCMA + 

0.9408(0.8906–0.9911)

 < 0.001

11.78

90.91

85.29

 Ps + CD41a-CD319 + 

0.8890(0.8119–0.9662)

 < 0.001

44.22

88.64

85.29

 Ps + CD41a-CD138 + BCMA + 

0.7961(0.6941–0.8981)

 < 0.001

6.61

79.55

70.59

 Ps + CD41a-CD138 + CD319 + 

0.7874(0.6871–0.8877)

 < 0.001

48.67

65.91

82.35

 Ps + CD41a-BCMA + CD319 + 

0.7059(0.5873–0.8245)

0.002

11.75

59.09

79.41

NDMM vs HDs (PB)

 CD41a-Ps + 

0.8596(0.7681–0.9511)

 < 0.001

27.02

81.82

76.67

 Ps + CD41a-CD138 + 

0.8636(0.7769–0.9504)

 < 0.001

5.105

93.94

68.75

 Ps + CD41a-BCMA + 

0.7325(0.6065–0.8584)

0.001

2.365

87.88

59.38

 Ps + CD41a-CD319 + 

0.7784(0.6643–0.8925)

 < 0.001

5.495

81.82

71.88

 Ps + CD41a-CD138 + BCMA + 

0.6795(0.5487–0.8102)

0.01

0.890

59.38

75.76

 Ps + CD41a-CD138 + CD319 + 

0.7476(0.6301–0.8652)

 < 0.001

3.340

57.58

84.38

 Ps + CD41a-BCMA + CD319 + 

0.8016(0.6946–0.9086)

 < 0.001

2.020

69.70

84.38

NDMM vs CR (BM)

 CD41a-Ps + 

0.7351(0.6258–0.8444)

 < 0.001

223.60

89.36

60.00

 Ps + CD41a-CD138 + 

0.7705(0.6689–0.8720)

 < 0.001

101.90

90.91

57.50

 Ps + CD41a-BCMA + 

0.7966(0.6992–0.8939)

 < 0.001

15.70

86.36

70.00

 Ps + CD41a-CD319 + 

0.7165(0.6070–0.8260)

 < 0.001

104.40

65.91

70.00

 Ps + CD41a-CD138 + BCMA + 

0.5858(0.4634–0.7082)

0.18

108.30

20.45

97.50

 Ps + CD41a-CD138 + CD319 + 

0.6463(0.5286–0.7604)

0.02

102.90

36.36

95.00

 Ps + CD41a-BCMA + CD319 + 

0.6011(0.4758–0.7237)

0.11

101.3

34.56

97.00

NDMM vs CR (PB)

 CD41a-Ps + 

0.8013(0.6917–0.9210)

 < 0.001

25.78

84.85

74.07

 Ps + CD41a-CD138 + 

0.7168(0.5776–0.8476)

0.004

5.180

55.17

90.91

 Ps + CD41a-BCMA + 

0.7168(0.5843–0.8494)

0.003

1.720

51.72

93.94

 Ps + CD41a-CD319 + 

0.6855(0.5465–0.8244)

0.010

3.950

44.83

93.94

 Ps + CD41a-CD138 + BCMA + 

0.6390(0.4961–0.7819)

0.060

0.890

55.17

75.76

 Ps + CD41a-CD138 + CD319 + 

0.6473(0.5098–0.7848)

0.050

2.230

58.62

69.70

 Ps + CD41a-BCMA + CD319 + 

0.7048(0.5721–0.8375)

0.006

1.990

75.86

69.70

MRD (−) vs MRD ( +) (BM)

 CD41a-Ps + 

0.9160(0.8471–0.9848)

 < 0.001

33.22

72.22

92.31

 Ps + CD41a-CD138 + 

0.8433(0.7427–0.9439)

 < 0.001

22.25

55.65

84.62

 Ps + CD41a-BCMA + 

0.8590(0.7530–0.9649)

 < 0.001

1.165

98.15

61.54

 Ps + CD41a-CD319 + 

0.8412(0.7436–0.9387)

 < 0.001

6.305

72.22

92.31