Fig. 1From: Detection of myeloma cell-derived microvesicles: a tool to monitor multiple myeloma loadThe value of microvesicles in bone marrow in monitoring MM tumor load. A The number of CD41a−Ps+ microvesicles from BM was significantly higher in NDMM compared with in CR and HDs. B The number of Ps+CD41a−CD138+, Ps+CD41a−BCMA+, Ps+CD41a−CD319+ microvesicles from BM was significantly higher in NDMM compared with in CR and HDs. C The number of CD41a−Ps+, Ps+CD41a−CD138+, Ps+CD41a−BCMA+, Ps+CD41a−CD319+ microvesicles from BM was significantly higher in the initial treatment group (NDMM) than in the remission group (CR) after treatment in 11 matched patients. D The number of BM microvesicles labeled CD41a−Ps+, Ps+CD41a−CD138+, Ps+CD41a−BCMA+, Ps+CD41a− CD319+ was positively correlated with the number of β2-MG and plasma cells in bone marrow smear. E ROC curve was analyzed Ps+CD41a−CD138+, Ps+CD41a−BCMA+, Ps+CD41a−CD319+ microvesicles from BM to distinguish the NDMM patients from HDs (left) and CR patients (right). F The number of BM microvesicles labeled CD41a−Ps+, Ps+CD41a−CD138+, Ps+CD41a−BCMA+, Ps+CD41a−CD319+ was significantly higher in MRD ( +) group compared with in MRD (−) group. G ROC curve was analyzed CD41a−Ps+, Ps+CD41a−CD138+, Ps+CD41a−BCMA+, Ps+CD41a−CD319+ microvesicles from BM to distinguish the MRD ( +) patients from MRD (−) patients. The number of Ps+CD41a− microvesicles has high accuracy (AUC > 0.9). H CD41a−Ps+ microvesicles were significantly reduced in the presence of Smi16a. I p-MLC-2 protein values decreased in the presence of Smi16aBack to article page