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Fig. 2 | Experimental Hematology & Oncology

Fig. 2

From: Wdr5 is essential for fetal erythropoiesis and hematopoiesis

Fig. 2

Wdr5 plays a pivotal role in the maintenance of fetal HSPCs function. A Representative FACS profile showing the LSK and HPC populations from CKO, heterozygous, and the littermate control embryos at E12.5. B Graph showing the percentage (left) and the absolute cell number (right) of the LSK and HPC populations in the FLs from CKO, heterozygous, and the littermate control embryos at E12.5 (n = 3–6 per genotype). C and D Representative FACS profiles showing the HSPCs in the FLs from CKO, heterozygous, and the littermate control embryos at E13.5 (C) and at E15.5 (D). E Graph showing the absolute cell number of HPC (left) and LSK (right) in the FLs from CKO, heterozygous, and the littermate control embryos at various developmental stages (n = 2–7 per genotype for each stage). F Graph showing the percentage (left) and the absolute cell number (right) of HSC, cKitSca1+, and CD150+CD48cKitSca1+ (CD150+) subsets in the FLs from CKO, heterozygous, and the littermate control embryos at E13.5 (n = 2–4 per genotype). G Graph showing the percentage (left) and the absolute cell number (right) of HSC, cKitSca1+, and CD150+CD48cKitSca1+ (CD150+) subsets in the FLs from CKO, heterozygous, and the littermate control embryos at E15.5 (n = 2–4 per genotype). H Graph showing the colony number derived from CKO and the control FLs in CFU assay. Statistical significance is indicated by ns for not statistically significant, *p < 0.05, **p < 0.01, ***p < 0.001, or ****p < 0.0001. Data are presented as mean ± SD

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