Fig. 1

Loss of Wdr5 mediated by Vav-iCre leads to embryonic lethality with defective erythropoiesis. A The offspring from the intercross between the male Wdr5^f/f mice and the female Wdr5^f/+, Vav-iCre at weaning age. B Representative photographs of the embryos (top) and the FLs (bottom) from CKO and the littermate control at E15.5. C The absolute cell number of FLs from CKO, heterozygous, and the littermate control embryos at E15.5 (n = 2–6 per genotype). D Graph showing the percentage (left) and  the absolute cell number (right) of CD71/Ter119 subsets in the FLs from CKO, heterozygous, and the littermate control embryos at E15.5 (n = 2–6 per genotype). E Graph showing the percentage (left) and the absolute cell number (right) of EryA/B/C subsets in the FLs from CKO, heterozygous, and the littermate control embryos at E15.5 (n = 2–6 per genotype). F Graph showing the percentage (left) and the absolute cell number (right) of the enucleated cells in the FLs from CKO, heterozygous, and the littermate control embryos at E15.5 (n = 2–6 per genotype). Statistical significance is indicated by ns for not statistically significant, *p < 0.05, **p < 0.01, ***p < 0.001, or ****p < 0.0001. Data are presented as mean ± SD