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Fig. 6 | Experimental Hematology & Oncology

Fig. 6

From: Synergistic effect of HDAC inhibitor Chidamide with Cladribine on cell cycle arrest and apoptosis by targeting HDAC2/c-Myc/RCC1 axis in acute myeloid leukemia

Fig. 6

The synergistic effect of Chidamide (CHI) and Cladribine (CLA) in c-MYC knockdown U937 cells versus the scramble shRNA control (shCTL) cells. (A) Cell viability effect of wide type (WT), shCTL, and shMYC-U937 cells. (B) The inhibition effect of CHI plus 0.01 μM CLA in shCTL, and shMYC-U937 cells. (C) The statistic histogram and (D) the flow cytometry scatters plot of apoptosis effect in shCTL versus shMYC-U937 cells that were treated by CHI alone, CLA alone, and two drugs combination for 48 h. (E) The flow cytometry histogram and (F) statistic histogram of cell cycle effect in shCTL versus shMYC-U937 cells that were treated by CHI alone, CLA alone, and two drugs combination for 48 h. *p < 0.05, **p < 0.01, ***p < 0.001

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