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Fig. 5 | Experimental Hematology & Oncology

Fig. 5

From: Synergistic effect of HDAC inhibitor Chidamide with Cladribine on cell cycle arrest and apoptosis by targeting HDAC2/c-Myc/RCC1 axis in acute myeloid leukemia

Fig. 5

The RNA-seq analysis of Chidamide (CHI) and Cladribine (CLA) in U937 cells and the change of c-Myc with different treatments. (A) The Venn plot shows the overlapped differential expression genes (DEGs) of U937 cells that were treated by CHI and CLA. The heat maps of the co-DEGs in U937 cells were treated with CHI (B) and CLA (C). (D) The enrichment analysis of the co-DEGs. (E) The expression of c-MYC in U937 cells and THP-1 cells treated with CHI alone, CLA alone, and two drugs combination for 48 h was detected by RT-qPCR. (F) Western blot of c-Myc in U937 cells and THP-1 cells that were treated by CHI alone, CLA alone, and two drugs combination for 48 h. *p < 0.05, **p < 0.01, ***p < 0.001

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Experimental Hematology & Oncology

ISSN: 2162-3619

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