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Fig. 4 | Experimental Hematology & Oncology

Fig. 4

From: Synergistic effect of HDAC inhibitor Chidamide with Cladribine on cell cycle arrest and apoptosis by targeting HDAC2/c-Myc/RCC1 axis in acute myeloid leukemia

Fig. 4

The synergistic apoptosis effect of Chidamide (CHI) and Cladribine (CLA) in AML cells. The flow cytometry scatters plot (A) and statistic histogram (B) of apoptosis effect in U937 cells and THP-1 cells that were treated by CHI alone, CLA alone, and two drugs combination for 48 h. (C) Western blot of caspase-9 and the cleaved one, caspase-3 and the cleaved one, PARP and the cleaved one in U937 cells and THP-1 cells that were treated with CHI alone, CLA alone, and two drugs combination for 48 h. *p < 0.05, **p < 0.01, ***p < 0.001

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