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Fig. 10 | Experimental Hematology & Oncology

Fig. 10

From: Synergistic effect of HDAC inhibitor Chidamide with Cladribine on cell cycle arrest and apoptosis by targeting HDAC2/c-Myc/RCC1 axis in acute myeloid leukemia

Fig. 10

The synergistic effect of Chidamide (CHI) and Cladribine (CLA) in AML primary cells. The cell proliferation assays (A) and the normalized isobologram plots of the combination of CHI and CLA (B) in primary cells. The statistic histogram (C) of apoptosis effect for primary cells that were treated by gradient concentration of CHI alone, CLA alone, and two drugs combination for 48 h. *p < 0.05, **p < 0.01, ***p < 0.001

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