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Table 3 Combination index (CI) values of Z138 and JVM2 cells treated with the combination of nutlin-3a and apcin for 48 h

From: p53 directly downregulates the expression of CDC20 to exert anti-tumor activity in mantle cell lymphoma

Nutlin-3a (μM)

Apcin (μM)

CI (Z138)

CI (JVM2)

0.5

50

0.82

0.50

1

50

0.56

0.51

2.5

50

0.69

0.79

0.5

75

0.65

0.57

1

75

0.66

0.59

2.5

75

0.70

0.59

0.5

100

0.62

0.63

1

100

0.76

0.71

2.5

100

0.78

0.88