Fig. 1

High expression of CDC20 in MCL patients and cell lines. A Relative CDC20 mRNA expression of PBMCs from 24 MCL patients and 7 healthy controls was detected by RT-qPCR. B Relative CDC20 mRNA expression of BMNCs from 17 MCL patients (including 11 cases with involved bone marrow and 6 cases with uninvolved bone marrow) and 10 healthy donors was detected by RT-qPCR. C Representative CDC20 IHC images of MCL patients and LRH patients (left, × 200 magnification; scale bar, 100 μm). Positive expression of CDC20 in 51 MCL patients and 12 LRH patients (as controls) was determined by MOD value (right). D Representative cyclin D1 and CDC20 IHC images of MCL patients (left, × 200 magnification; scale bar, 100 μm). The positive relationship between cyclin D1 expression and CDC20 expression was confirmed by IHC staining in 51 MCL patients (Right). E Relative TP53 and CDC20 mRNA expression of MCL cell lines Jeko, Mino, Z138 and JVM2 was detected by RT-qPCR, with PBMCs as control. F Relative p53 and CDC20 protein expression of MCL cell lines Jeko, Mino, Z138 and JVM2 was analyzed by WB, with PBMCs as control. *P < 0.05, **P < 0.01, ***P < 0.001, ns meant P > 0.05