Fig. 5

circPRDM4 facilitates tumor growth and immune escape in vivo. A Illustration of the construction of the PDX mouse model and adoptive human TIL-CD8⁺ T cell transfer. B Representative tumor images of each group of PDX mice at the end of treatment. C Tumor weights of the xenografts with circPRDM4 overexpression at the end of treatment. D Tumor weights of the xenografts with circPRDM4 knockdown at the end of treatment. E Tumor growth curves of the xenografts with circPRDM4 overexpression. F Tumor growth curves of the xenografts with circPRDM4 knockdown. G Expression levels of circPRDM4 in xenografts with circPRDM4 overexpression. H Expression levels of circPRDM4 in xenografts with circPRDM4 knockdown. I Expression levels of CD274 in xenografts with circPRDM4 overexpression. J Expression levels of CD274 in xenografts with circPRDM4 knockdown. K Representative immunofluorescence images showing infiltrated CD8⁺ cells in each group of xenografts. Data are shown as mean ± SEM. **, P < 0.01; ***, P < 0.001